Understanding Autoinflammatory Diseases
Autoinflammatory diseases are a group of rare and diverse conditions caused by errors in the immune system. These diseases can affect anyone, regardless of age or background, and can significantly impact the quality of life. However, these diseases can be managed effectively with the correct information and support.
List of Autoinflammatory Diseases
Below is a list of some of the most common monogenic autoinflammatory diseases. Click on each condition to learn more about its symptoms, causes, treatments, etc.
These are the most common Monogenic Autoinflammatory Diseases in our region:
Familial Mediterranean Fever (FMF)
Familial Mediterranean Fever is a genetic autoinflammatory disease characterized by recurrent, similar episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever.
Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS)
TRAPS is a genetic disorder characterized by recurrent episodes of fever, abdominal pain, and skin rashes. These episodes can last from a few days to a few weeks.
Cryopyrin-Associated Periodic Syndromes (CAPS)
CAPS is a group of autoinflammatory syndromes that include distinct diseases with different severi-ty: Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), and Neonatal-Onset Multisystem Inflammatory Disease (NOMID). Common symptoms include recurrent episodes of fever, skin rash, and joint pain.
Mevalonate Kinase Deficiency (MKD) / Hyper IgD Syndrome (HIDS) /
MKD/HIDS is a rare genetic disorder characterized by recurrent episodes of fever, abdominal pain, and skin rash. These episodes are often triggered by physical or emotional stress.
Most common Complex
Autoinflammatory Diseases:
Behçet's Disease
Behçet’s Disease is a rare disorder that causes blood vessel inflammation throughout the body. Symptoms include recurrent mouth and/or genital sores, eye inflammation, skin rashes, and lesions.
Non-genetic periodic
fever syndromes:
PFAPA Syndrome
This is the most common nongenetic periodic fever syndrome. It’s characterized by recurrent episodes of fever, mouth sores, sore throat, and swollen lymph nodes.
Learn More
Each of these diseases has unique characteristics and requires different approaches to treatment. Click on each disease to learn more about its symptoms, causes, and treatment options.