Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS)

Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS) is a rare genetic autoinflammatory disease. Recurrent episodes of fever, abdominal pain, and skin rashes characterize it.

What is TRAPS?

TRAPS is an autoinflammatory condition that causes recurrent episodes, or attacks, of fever, skin rash, and pain in various parts of the body. These attacks can last from a few days to a few weeks, prolonged attacks (more then 1 week) are typical. The frequency and severity of these attacks can vary significantly from person to person.

Causes of TRAPS

TRAPS is caused by mutations in the TNFRSF1A gene, which provides instructions for making a protein that plays a crucial role in regulating inflammation in the body. Mutations in the TNFRSF1A gene produce an abnormal protein, leading to uncontrolled inflammation and the symptoms of TRAPS.

Symptoms of TRAPS

The most common symptoms of TRAPS include:

  • Recurrent fevers
  • Abdominal pain
  • Skin rash
  • Muscle pain
  • Swelling around the eyes

Symptoms usually begin in early childhood, but in some cases, they may not appear until adulthood. Usually a close family member is also suffering from similar problems.

Diagnosis of TRAPS

Diagnosing TRAPS can be challenging due to the variability in symptoms and their episodic nature. Diagnosis is typically based on clinical signs and may be confirmed by genetic testing to identify mutations in the TNFRSF1A gene.

Treatment of TRAPS

While there is currently no cure for TRAPS, treatments are available to help manage symptoms and prevent complications. Treatment often involves medications that reduce inflammation and suppress the immune system.

Living with TRAPS

Living with TRAPS can be challenging, but with the proper treatment and support, most individuals with TRAPS can lead healthy and productive lives. Regular follow-ups with healthcare providers, a healthy lifestyle, and a strong support network can significantly improve the quality of life for individuals with TRAPS.

If you or a loved one has been diagnosed with TRAPS, remember you are not alone. Join our Community to connect with others who understand what you’re going through.

Tisztelt Szülő/ Háziorvos Kolléga!

Ha Ön úgy gondolja, hogy visszatérő lázas gyermekénél/betegénél autoinflammatórikus betegség merül fel, itt tud ambuláns kivizsgálásra időpontot kérni:

Előjegyzés

Dear Parent or Health Care Professional,

If you suspect that a child or patient with recurrent fever may have an autoinflammatory disease, you can schedule an outpatient examination here:

Appointment